Hayashi M, Numaguchi M, Ohkubo N, Yaoi Y
Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
Am J Med Sci. 1998 Apr;315(4):251-7. doi: 10.1097/00000441-199804000-00007.
Macrophage colony-stimulating factor (M-CSF) is a characteristic cytokine that plays an essential role in placenta maintenance, and thrombin-antithrombin III complex (TAT) is a hemostatic marker that is remarkably altered both in normal pregnancy and in preeclampsia. The present study was designed in order to show various levels of M-CSF and TAT in pregnancies. Peripheral blood was collected from 49 subjects, of whom 31 were normal pregnant women consisting of the four groups (namely 10th, 20th, 30th, and 38th weeks of gestation), 13 were preeclamptic pregnant women (37th week of gestation; mean blood pressure, 158/99 mm Hg), and 5 were nonpregnant controls. We compared blood M-CSF and TAT levels among them. Results showed that blood M-CSF and TAT levels increased significantly with gestational age. Furthermore, the ratio of increase in M-CSF was significantly lower than that in TAT in normal pregnant women compared with controls. In contrast, the ratio of increase in M-CSF was significantly higher than that in TAT in preeclamptic women compared with normal pregnant women. These results concerning the ratio of increase in M-CSF and TAT have not been reported. These findings show that M-CSF level increases significantly in preeclampsia even in its earlier stage, exhibiting a systolic blood pressure of less than 160 mm Hg.
巨噬细胞集落刺激因子（M-CSF）是一种在胎盘维持中起关键作用的特征性细胞因子，而凝血酶-抗凝血酶III复合物（TAT）是一种止血标志物，在正常妊娠和子痫前期均有显著变化。本研究旨在展示不同孕期M-CSF和TAT的水平。从49名受试者中采集外周血，其中31名是正常孕妇，分为四组（即妊娠第10周、第20周、第30周和第38周），13名是子痫前期孕妇（妊娠第37周；平均血压158/99 mmHg），5名是非妊娠对照组。我们比较了他们血液中M-CSF和TAT的水平。结果显示，血液中M-CSF和TAT水平随孕周显著升高。此外，与对照组相比，正常孕妇中M-CSF的升高比例显著低于TAT。相反，与正常孕妇相比，子痫前期孕妇中M-CSF的升高比例显著高于TAT。关于M-CSF和TAT升高比例的这些结果尚未见报道。这些发现表明，即使在子痫前期早期，收缩压低于160 mmHg时，M-CSF水平也会显著升高。
