Henry J L
Brain Res. 1976 Sep 24;114(3):439-51. doi: 10.1016/0006-8993(76)90965-3.
A correlation was made between the effects of synthetic substance P (ssP) on spinal dorsal horn neurones and the responses of these neurones to natural peripheral stimulation. It was found that ssP caused excitation only of those units which were excited by noxious radiant heat applied to the skin. ssP also caused a small facilitation of the excitatory response to this noxious stimulus and, in two cases, led to a response to noxious heat of units which had previously been unaffected by this stimulus. The ratio of ssP sensitive to insensitive units was highest in the deeper parts of the dorsal horn. Excitation by ssP showed a positive correlation to excitation by bradykinin. These results suggest that substance P may be involved in excitatory spinal processes and that its actions may be associated specifically with nociception.
对合成P物质（ssP）对脊髓背角神经元的作用与这些神经元对自然外周刺激的反应之间进行了相关性研究。结果发现，ssP仅能兴奋那些受到皮肤有害辐射热刺激时被兴奋的神经元。ssP还能对这种有害刺激的兴奋反应产生轻微的易化作用，并且在两例中，能使先前对该刺激无反应的神经元对有害热产生反应。在背角较深层部位，ssP敏感神经元与不敏感神经元的比例最高。ssP引起的兴奋与缓激肽引起的兴奋呈正相关。这些结果表明，P物质可能参与脊髓的兴奋过程，且其作用可能与伤害感受特异性相关。
