Ellenrieder V, Weidenbach H, Frickhofen N, Michel D, Prümmer O, Klatt S, Bernas O, Mertens T, Adler G, Beckh K
Department of Gastroenterology, University of Ulm, Germany.
J Hepatol. 1998 Jan;28(1):34-9. doi: 10.1016/s0168-8278(98)80199-2.
BACKGROUND/AIMS: A causative role of hepatitis C virus infection (HCV) has been discussed in the pathogenesis of mixed cryoglobulinaemia and in B-cell non-Hodgkin's lymphoma. No data are available concerning the newly discovered hepatitis G virus (HGV) and extrahepatic manifestations such as haematological malignancies. But, HCV and HGV most probably belong to the same family of Flavivirus. Consequently, we looked for the prevalence of HCV, HGV and cryoglobulins in patients with B-cell non-Hodgkin's lymphoma.
Serum samples from 69 patients with non-Hodgkin's lymphoma were studied. Diagnosis of non-Hodgkin's lymphoma was established according to the Kiel classification. Active HCV- and HGV infections were investigated using polymerase chain reaction for detection of viral RNA. Cryoglobulins were detected from serum and monoclonal immunoglobulin components were analysed with immunofixation electrophoresis. In addition, we assessed the clinical course of HCV- and HGV-infected patients under chemotherapy.
Three of 69 (4.3%) patients with B-cell non-Hodgkin's lymphoma were HCV-infected and nine non-Hodgkin's lymphoma patients (13.0%) were positive for hepatitis G virus RNA. All HGV infected patients were suffering from low-grade non-Hodgkin's lymphoma. No HGV-infected patient was co-infected by HCV and neither HCV- nor HGV-infected patients showed clinical signs of chronic liver disease before, during or after chemotherapy. Serum samples from all patients were devoid of cryoglobulins.
HCV seems to have no significance for the pathogenesis of non-Hodgkin's lymphoma in Germany. The increased prevalence of hepatitis G (16.3%) in patients with low-grade non-Hodgkin's lymphoma could suggest a pathological consequence of HGV infection outside of the liver. Evidence of clinically relevant hepatic disease in HGV infected patients was not obtained. Further, chemotherapy does not seem to affect the subsequent clinical course of HGV infection.
背景/目的：丙型肝炎病毒感染（HCV）在混合性冷球蛋白血症和B细胞非霍奇金淋巴瘤的发病机制中所起的致病作用已被讨论。关于新发现的庚型肝炎病毒（HGV）及血液系统恶性肿瘤等肝外表现尚无相关数据。但是，HCV和HGV很可能属于黄病毒科的同一属。因此，我们研究了B细胞非霍奇金淋巴瘤患者中HCV、HGV及冷球蛋白的流行情况。
对69例非霍奇金淋巴瘤患者的血清样本进行研究。非霍奇金淋巴瘤的诊断依据基尔分类法确定。采用聚合酶链反应检测病毒RNA来研究HCV和HGV的活动性感染。从血清中检测冷球蛋白，并用免疫固定电泳分析单克隆免疫球蛋白成分。此外，我们评估了化疗期间HCV和HGV感染患者的临床病程。
69例B细胞非霍奇金淋巴瘤患者中有3例（4.3%）感染HCV，9例非霍奇金淋巴瘤患者（13.0%）庚型肝炎病毒RNA呈阳性。所有HGV感染患者均患有低度非霍奇金淋巴瘤。没有HGV感染患者合并HCV感染，化疗前、化疗期间及化疗后，HCV和HGV感染患者均未出现慢性肝病的临床症状。所有患者的血清样本均无冷球蛋白。
在德国，HCV似乎对非霍奇金淋巴瘤的发病机制无影响。低度非霍奇金淋巴瘤患者中庚型肝炎病毒感染率增加（16.3%）可能提示HGV肝外感染的病理后果。未获得HGV感染患者有临床相关肝病的证据。此外，化疗似乎不影响HGV感染的后续临床病程。
