Bertoni F, Sanna P, Zucca E, Roggero E, Cavalli F
Servizio Oncologico Cantonale, Ospedale San Giovanni, 6500 Bellinzona, Switzerland.
Oncol Rep. 1998 May-Jun;5(3):605-7. doi: 10.3892/or.5.3.605.
Approximately one-fourth of non-Hodgkin's lymphomas originate in extranodal sites. True primary involvement of soft tissues is quite uncommon and only a few well-documented cases are reported in the literature. We report four cases of primary skeletal muscle lymphoma. Three of the four cases presented with a diffuse large B-cell lymphoma. The clinical history of two cases confirmed that soft tissue masses should be promptly biopsied, since the differential diagnosis comprises benign lesions, as well as sarcoma, primary or metastatic carcinoma, melanoma and lymphoma. As lymphomas have to be treated primarily according to the tumour histology and disease extent, treatment of primary skeletal muscle lymphomas must be planned with these factors in mind. For patients presenting with diffuse large cell histology, a CHOP-like regimen alone or a combined modality with radiotherapy seem to be proper approaches.
大约四分之一的非霍奇金淋巴瘤起源于结外部位。软组织真正的原发性受累相当罕见，文献中仅报道了少数有充分记录的病例。我们报告4例原发性骨骼肌淋巴瘤。4例中有3例表现为弥漫性大B细胞淋巴瘤。2例的临床病史证实，软组织肿块应及时进行活检，因为鉴别诊断包括良性病变，以及肉瘤、原发性或转移性癌、黑色素瘤和淋巴瘤。由于淋巴瘤必须主要根据肿瘤组织学和疾病范围进行治疗，原发性骨骼肌淋巴瘤的治疗必须考虑这些因素。对于表现为弥漫性大细胞组织学的患者，单独使用类似CHOP的方案或联合放疗似乎是合适的方法。
