维甲酸与转移性肾细胞癌
Retinoids and metastatic renal cell carcinoma.
作者信息
Paule B, Brion N
机构信息
Service de Rhumatologie, Centre Hospitalier de Bicêtre, Le Kremlin-Bicêtre.
出版信息
Ann Med Interne (Paris). 1997;148(7):496-501.
The treatment of metastatic renal cell carcinoma remains unsatisfactory. Several therapeutic trials with retinoids and r interferon alpha (r IFN alpha) suggest a synergic antiproliferative effect between retinoid acid and r IFN alpha. Pharmacokinetic data and the mechanism of antiproliferative effects of retinoids are discussed. The induction of growth arrest is related to the expression of specific retinoid receptors. Further investigations are required in order to target the patient population which requires this therapy.
转移性肾细胞癌的治疗仍不尽人意。几项使用维甲酸和r干扰素α（r IFNα）的治疗试验表明，维甲酸和r IFNα之间存在协同抗增殖作用。文中讨论了维甲酸的药代动力学数据和抗增殖作用机制。生长停滞的诱导与特定维甲酸受体的表达有关。为了确定需要这种治疗的患者群体，还需要进一步研究。
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