De Bandt M
Laboratoire d'Immuno-Rhumatologie, Hôpital Bichat, Paris.
Ann Med Interne (Paris). 1997;148(8):542-62.
ANCA (antineutrophil cytoplasmic antibodies) are a growing class of interest; these antibodies target lysosomial enzymes from polymorphonuclear cells. They represent diagnosis tools and prognosis markers in systemic vasculitis (Wegener's granulomatosis and microscopic polyangiitis). They are also detected in other chronic inflammatory diseases as lupus and rheumatoid arthritis. Their description, ten years ago, led to a huge amount of clinical and experimental work. The role of ANCA as pathogenic auto-antibodies in the disease is supported in numerous studies giving new insights into the pathogenesis of systemic vasculitis.
抗中性粒细胞胞浆抗体（ANCA）是一类越来越受关注的物质；这些抗体靶向多形核细胞的溶酶体酶。它们是系统性血管炎（韦格纳肉芽肿和显微镜下多血管炎）的诊断工具和预后标志物。在狼疮和类风湿关节炎等其他慢性炎症性疾病中也能检测到它们。十年前对它们的描述引发了大量的临床和实验工作。众多研究支持ANCA作为疾病中的致病性自身抗体的作用，这为系统性血管炎的发病机制提供了新的见解。
