Kusumoto Y, Komura K
Department of Anatomy, Hiroshima University School of Medicine, Japan.
Hiroshima J Med Sci. 1997 Dec;46(4):109-14.
The vitamin A uptake cells in the anterior pituitary, thyroid gland, and pancreas of Japanese quails, coturnix coturnix japonica, were examined by the use of Sudan III staining, toluidine blue staining, fluorescence microscopy and electron microscopy. After excess vitamin A administration, most of interstitial cells, corresponding to fibroblasts, increased markedly the size and number of lipid droplets in the cytoplasm which emitted vitamin A fluorescence intensively. The reactions to vitamin A administration were in parallel with the vitamin A dosage. In particular, the cells of the thyroid gland and pancreas were comparable to the Ito cells of the liver in their vitamin A uptake capacity. The present study demonstrates that interstitial cells either identical with or closely related to the Ito cells of the liver are widely distributed in the connective tissue of these endocrine organs. The possible physiological roles of the vitamin A uptake cells and also the species difference in the vitamin A uptake capacity of these cells are discussed.
通过使用苏丹III染色、甲苯胺蓝染色、荧光显微镜和电子显微镜，对日本鹌鹑（Coturnix coturnix japonica）垂体前叶、甲状腺和胰腺中的维生素A摄取细胞进行了检查。过量给予维生素A后，大多数对应于成纤维细胞的间质细胞显著增加了细胞质中脂质小滴的大小和数量，这些脂质小滴强烈发出维生素A荧光。对维生素A给药的反应与维生素A剂量平行。特别是，甲状腺和胰腺的细胞在维生素A摄取能力方面与肝脏的伊藤细胞相当。本研究表明，与肝脏伊藤细胞相同或密切相关的间质细胞广泛分布于这些内分泌器官的结缔组织中。讨论了维生素A摄取细胞可能的生理作用以及这些细胞在维生素A摄取能力方面的物种差异。
