不宁腿综合征和抗精神病药物所致静坐不能患者周期性肢体运动的多导睡眠图研究

A polysomnographic study on periodic limb movements in patients with restless legs syndrome and neuroleptic-induced akathisia.

作者信息

Inami Y, Horiguchi J, Nishimatsu O, Sasaki A, Sukegawa T, Katagiri H, Yamawaki S

机构信息

Department of Neuropsychiatry, Ehime University School of Medicine, Japan.

出版信息

Hiroshima J Med Sci. 1997 Dec;46(4):133-41.

PMID:9538563

Abstract

Eighteen patients with restless legs syndrome (RLS) and 4 patients with neuroleptic-induced akathisia (NIA) underwent all-night polysomnographic recordings before and during clonazepam treatment. Ten normal control subjects and 4 non-akathitic psychiatric patients treated with neuroleptics underwent polysomnographic recordings, which were compared with those of the RLS and NIA patients, respectively. Daily treatment with 0.5 to 3 mg clonazepam improved subjective complaints of 17 out of 18 patients with RLS and all the 4 patients with NIA. All the 18 patients with RLS exhibited periodic limb movements (PLM) on the polysomnograms before treatment, but only 2 of 10 control subjects exhibited PLM. Three of the 4 patients with NIA exhibited PLM, but none of the 4 controls on neuroleptics showed PLM. Clonazepam decreased the total number of PLM per hour in patients of both RLS and NIA.

摘要

18例不安腿综合征（RLS）患者和4例抗精神病药所致静坐不能（NIA）患者在氯硝西泮治疗前及治疗期间进行了整夜多导睡眠图记录。10名正常对照者和4例接受抗精神病药治疗的无静坐不能的精神科患者进行了多导睡眠图记录，并分别与RLS和NIA患者的记录进行比较。每天使用0.5至3毫克氯硝西泮治疗改善了18例RLS患者中的17例以及所有4例NIA患者的主观症状。所有18例RLS患者在治疗前的多导睡眠图上均表现出周期性肢体运动（PLM），但10名对照者中只有2例表现出PLM。4例NIA患者中有3例表现出PLM，但4例接受抗精神病药治疗的对照者均未表现出PLM。氯硝西泮减少了RLS和NIA患者每小时PLM的总数。