Grav H J, Blix A S
Can J Physiol Pharmacol. 1976 Jun;54(3):409-12. doi: 10.1139/y76-057.
The respiratory characteristics of mitochondria isolated from the subcutaneous brown adipose tissue of newborn harp seals indicate that the tissue is thermogenically active. Temperature recordings in vivo revealed, in fact, that the tissue was maintained at a temperature close to that of the body core during immersion of the pups in ice-water. Beta-adrenergic blockade markedly increased the cooling rates at both locations in ice-water, while curarization, accompanied by artificial respiration did not. We conclude that nonshivering thermogenesis through activated brown adipose tissue plays a decisive role in the defence against cold in the newborn harp seal.
从新生格陵兰海豹皮下棕色脂肪组织分离出的线粒体的呼吸特性表明，该组织具有产热活性。事实上，体内温度记录显示，在幼崽浸入冰水中时，该组织的温度保持在接近身体核心温度的水平。β-肾上腺素能阻断显著提高了在冰水中两个部位的降温速率，而箭毒化并伴有人工呼吸时则没有。我们得出结论，通过激活棕色脂肪组织进行的非颤抖性产热在新生格陵兰海豹抵御寒冷中起决定性作用。
