丝氨酸蛋白酶抑制剂构象图谱。
An atlas of serpin conformations.
作者信息
Whisstock J, Skinner R, Lesk A M
机构信息
Department of Haematology, University of Cambridge, MRC Centre, UK.
出版信息
Trends Biochem Sci. 1998 Feb;23(2):63-7. doi: 10.1016/s0968-0004(97)01172-9.
PMID:9538691
Abstract
The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed-->relaxed (S-->R) transition. This article is a guide to the known serpin conformations and their biological significance.
摘要
丝氨酸蛋白酶抑制剂（serpins）是一类能够抑制胰凝乳蛋白酶样丝氨酸蛋白酶的蛋白质家族，其作用机制独特，涉及一种被称为应激态到松弛态（S→R）转变的大型构象变化。本文是关于已知丝氨酸蛋白酶抑制剂构象及其生物学意义的指南。
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