肾功能不全患者通过透析清除盐酸金刚烷胺。
Removal of amantadine hydrochloride by dialysis in patients with renal insufficiency.
作者信息
Ing T S, Mahurkar S D, Dunea G, Hayashi J A, Klawans H L, Markey W S
出版信息
Can Med Assoc J. 1976 Sep 18;115(6):515.
Abstract
Two patients with Parkinson's disease and renal insufficiency had excessively high concentrations of amantadine hydrochloride in the blood. The amounts of the drug removed by hemodialysis and peritoneal dialysis were small. However, since extrarenal elimination is negligible in such patients, frequently repeated dialysis may be required to remove the drug.
摘要
两名患有帕金森病且肾功能不全的患者血液中盐酸金刚烷胺浓度过高。血液透析和腹膜透析清除该药物的量很少。然而，由于此类患者肾外清除可忽略不计，可能需要频繁重复透析以清除该药物。
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本文引用的文献
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Amantadine toxicity in a patient with renal insufficiency.肾功能不全患者的金刚烷胺中毒
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