Pecon Slattery J, O'Brien S J
Laboratory of Genomic Diversity, Frederick Cancer and Research and Development Center, National Cancer Institute, Maryland 21702, USA.
Genetics. 1998 Mar;148(3):1245-55. doi: 10.1093/genetics/148.3.1245.
The 37 species of modern cats have evolved from approximately eight phylogenetic lineages within the past 10 to 15 million years. The Felidae family has been described with multiple measures of morphologic and molecular evolutionary methods that serve as a framework for tracking gene divergence during brief evolutionary periods. In this report, we compare the mode and tempo of evolution of noncoding sequences of a large intron within Zfy (783 bp) and Zfx (854 bp), homologous genes located on the felid Y and X chromosomes, respectively. Zfy sequence variation evolves at about twice the rate of Zfx, and both gene intron sequences track feline hierarchical topologies accurately. As homoplasies are infrequent in patterns of nucleotide substitution, the Y chromosome sequence displays a remarkable degree of phylogenetic consistency among cat species and provides a highly informative glimpse of divergence of sex chromosome sequences in Felidae.
在过去的1000万至1500万年里，现代猫科动物的37个物种是从大约8个系统发育谱系进化而来的。猫科动物家族已经通过多种形态学和分子进化方法进行了描述，这些方法为追踪短时间进化过程中的基因分歧提供了一个框架。在本报告中，我们比较了Zfy（783 bp）和Zfx（854 bp）内一个大内含子的非编码序列的进化模式和速度，这两个同源基因分别位于猫科动物的Y染色体和X染色体上。Zfy序列变异的进化速度约为Zfx的两倍，并且两个基因内含子序列都能准确追踪猫科动物的等级拓扑结构。由于核苷酸替代模式中的同塑性很少见，Y染色体序列在猫科物种之间显示出显著程度的系统发育一致性，并为猫科动物性染色体序列的分歧提供了极具信息价值的一瞥。
