获得性毒力基因的差异模式可区分沙门氏菌菌株。
Differential patterns of acquired virulence genes distinguish Salmonella strains.
作者信息
Conner C P, Heithoff D M, Julio S M, Sinsheimer R L, Mahan M J
机构信息
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4641-5. doi: 10.1073/pnas.95.8.4641.
Abstract
Analysis of several Salmonella typhimurium in vivo-induced genes located in regions of atypical base composition has uncovered acquired genetic elements that cumulatively engender pathogenicity. Many of these regions are associated with mobile elements, encode predicted adhesin and invasin-like functions, and are required for full virulence. Some of these regions distinguish broad host range from host-adapted Salmonella serovars and may contribute to inherent differences in host specificity, tissue tropism, and disease manifestation. Maintenance of this archipelago of acquired sequence by selection in specific hosts reveals a fossil record of the evolution of pathogenic species.
摘要
对位于非典型碱基组成区域的几种鼠伤寒沙门氏菌体内诱导基因的分析，揭示了累积产生致病性的获得性遗传元件。这些区域中的许多与移动元件相关，编码预测的粘附素和侵袭素样功能，并且是完全毒力所必需的。其中一些区域区分了广泛宿主范围的沙门氏菌血清型和宿主适应性血清型，可能导致宿主特异性、组织嗜性和疾病表现的内在差异。通过在特定宿主中进行选择来维持这一获得性序列的群岛，揭示了致病物种进化的化石记录。
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