淋巴细胞颗粒介导的细胞死亡。 - Suppr

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超能文献

Lymphocyte granule-mediated cell death.

作者信息

Trapani J A, Jans D A, Sutton V R

机构信息

John Connell Laboratory, Austin Research Institute, Heidelberg, Australia.

出版信息

Springer Semin Immunopathol. 1998;19(3):323-43. doi: 10.1007/BF00787229.

DOI:10.1007/BF00787229

PMID:9540160

Abstract

摘要

相似文献

Lymphocyte granule-mediated cell death.淋巴细胞颗粒介导的细胞死亡。

Springer Semin Immunopathol. 1998;19(3):323-43. doi: 10.1007/BF00787229.

The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology.淋巴细胞颗粒胞吐作用与死亡受体介导的细胞毒性在病毒病理生理学中的相对作用。

J Virol. 1998 Jan;72(1):1-9. doi: 10.1128/JVI.72.1.1-9.1998.

Mechanism of lymphocyte-mediated cytotoxicity.淋巴细胞介导的细胞毒性机制。

Annu Rev Immunol. 1985;3:31-58. doi: 10.1146/annurev.iy.03.040185.000335.

Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.Fas配体在CD8 + 细胞毒性T淋巴细胞和自然杀伤细胞胞质颗粒中的定位：Fas配体在细胞毒性颗粒外排模型中的作用。

Biochem Biophys Res Commun. 2002 Aug 16;296(2):328-36. doi: 10.1016/s0006-291x(02)00841-0.

Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production.比较原代人细胞毒性 T 细胞和自然杀伤细胞的反应揭示了裂解颗粒胞吐的相似分子要求，但细胞因子产生存在差异。

Blood. 2013 Feb 21;121(8):1345-56. doi: 10.1182/blood-2012-07-442558. Epub 2013 Jan 2.

Granule-mediated cytotoxicity.颗粒介导的细胞毒性。

Results Probl Cell Differ. 1999;23:103-25. doi: 10.1007/978-3-540-69184-6_6.

Defective cytotoxic granule-mediated cell death pathway impairs T lymphocyte homeostasis.细胞毒性颗粒介导的细胞死亡途径缺陷会损害T淋巴细胞稳态。

Curr Opin Rheumatol. 2003 Jul;15(4):436-45. doi: 10.1097/00002281-200307000-00011.

[Large granule-containing lymphocytes--a new concept in hematology and immunology].[含大颗粒淋巴细胞——血液学和免疫学中的一个新概念]

Gematol Transfuziol. 1985 Sep;30(9):45-43.

Inhibition of NK and ADCC activity by antibodies against purified cytoplasmic granules from rat LGL tumors.用抗大鼠大颗粒淋巴细胞（LGL）肿瘤纯化细胞质颗粒的抗体抑制自然杀伤（NK）和抗体依赖的细胞介导的细胞毒性（ADCC）活性。

J Leukoc Biol. 1987 Dec;42(6):642-52. doi: 10.1002/jlb.42.6.642.

The role of cytoplasmic granules in cytotoxicity by large granular lymphocytes and cytotoxic T lymphocytes.细胞质颗粒在大颗粒淋巴细胞和细胞毒性T淋巴细胞的细胞毒性中的作用。

Adv Exp Med Biol. 1985;184:121-38. doi: 10.1007/978-1-4684-8326-0_9.

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Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.作为穿孔素介导的细胞溶解抑制剂的取代芳基磺酰胺

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.细菌毒素介导颗粒酶B的胞质递送：有证据表明，除形成跨膜孔道外，内体破坏也是穿孔素的一项重要功能。

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本文引用的文献

The ICE family of cysteine proteases as effectors of cell death.ICE 家族胱氨酸蛋白酶作为细胞死亡的效应因子。

Cell Death Differ. 1996 Jul;3(3):255-67.

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.穿孔素在生物合成过程中通过蛋白水解切割被激活，从而暴露出一个磷脂结合C2结构域。

EMBO J. 1997 Dec 15;16(24):7287-96. doi: 10.1093/emboj/16.24.7287.

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes.Bcl-2可防止穿孔素和颗粒酶B诱导的细胞凋亡，但不能防止全细胞毒性淋巴细胞介导的细胞凋亡。

J Immunol. 1997 Jun 15;158(12):5783-90.

A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).一个由10种小鼠卵清蛋白丝氨酸蛋白酶抑制剂组成的新家族，包括蛋白酶抑制剂8的两个同源物和颗粒酶B抑制剂（蛋白酶抑制剂9）的两个同源物。

J Biol Chem. 1997 Jun 13;272(24):15434-41. doi: 10.1074/jbc.272.24.15434.

Inherited disorders of glycoprotein synthesis: cell biological insights.糖蛋白合成的遗传性疾病：细胞生物学见解

Proc Soc Exp Biol Med. 1997 Jun;215(2):145-57. doi: 10.3181/00379727-215-44121.

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.颗粒酶B（GraB）可自主穿过细胞膜，穿孔素启动细胞凋亡以及颗粒酶B的核定位。

J Exp Med. 1997 Mar 3;185(5):855-66. doi: 10.1084/jem.185.5.855.

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.DFF是一种异二聚体蛋白，在细胞凋亡过程中，它在半胱天冬酶-3下游发挥作用，触发DNA片段化。

Cell. 1997 Apr 18;89(2):175-84. doi: 10.1016/s0092-8674(00)80197-x.

Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.类ICE蛋白酶和颗粒酶B对Nedd2前体的加工处理。

Genes Cells. 1996 Jul;1(7):673-85. doi: 10.1046/j.1365-2443.1996.00255.x.

Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins.519（颗粒溶素）的加工、亚细胞定位及功能，519是一种与小的溶解性颗粒蛋白具有同源性的人类晚期T细胞激活分子。

J Immunol. 1997 Mar 15;158(6):2680-8.

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases.细胞毒性T淋巴细胞（CTL）颗粒胞吐作用导致的靶细胞裂解独立于ICE/Ced-3家族蛋白酶。

Immunity. 1997 Feb;6(2):209-15. doi: 10.1016/s1074-7613(00)80427-6.

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