Schreiber J, Müller E, Becker W M, Zabel P, Schlaak M, Amthor M
Forschungszentrum Borstel, Medizinische Klinik.
Pneumologie. 1998 Jan;52(1):61-5.
A 51-year old woman developed hypersensitivity pneumonitis to spinach powder, which is used as a food dye. The diagnosis was confirmed by demonstration of IgG2-antibodies in the patient's serum to distinct bands of spinach extract by Western blotting. Furthermore an exposure test with the natural allergen was positive. Severe disease with fever, chills and dyspnoea developed after inhalation of native spinach powder. Arterial pO2 dropped significantly and pulmonary function tests showed severe restrictive impairment and reduction of diffusion capacity. Leucocyte count and the serum concentrations of the cytokines TNF alpha and IL6 and of the soluble IL2-receptor rose significantly in peripheral blood, whereas the concentration of neopterine did not change. 24 hours after exposure bronchoalveolar lavage showed an increase of neutrophils. In lung parenchyma mononuclear interstitial infiltrates and an epitheloid cell granuloma were seen.
一名51岁女性对用作食用色素的菠菜粉发生了过敏性肺炎。通过蛋白质印迹法在患者血清中检测到针对菠菜提取物不同条带的IgG2抗体，从而确诊。此外，天然过敏原激发试验呈阳性。吸入天然菠菜粉后出现了伴有发热、寒战和呼吸困难的严重疾病。动脉血氧分压显著下降，肺功能测试显示严重的限制性损害和弥散能力降低。外周血白细胞计数以及细胞因子TNF-α、IL-6和可溶性IL-2受体的血清浓度显著升高，而蝶呤浓度未发生变化。接触24小时后，支气管肺泡灌洗显示中性粒细胞增多。肺实质可见单核细胞间质浸润和上皮样细胞肉芽肿。
