具有H1抗组胺作用的酰胺衍生物。
Amide derivatives with H1-antihistaminic effect.
作者信息
Saturnino C, Saturnino P, De Martino G, Lancelot J C, Perrine D, Boureau R, Robba M
机构信息
Facoltà di Farmacia, Università degli Studi di Salerno, Penta-Salerno, Italy.
出版信息
Pharm Acta Helv. 1998 Jan;72(5):279-83. doi: 10.1016/s0031-6865(97)00025-3.
PMID:9540460
Abstract
The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.
摘要
已开展了一系列作为H1抗组胺剂的N-氨基烷基乙酰胺的合成及其构效关系研究。通过测量组胺诱导的豚鼠离体回肠收缩抑制作用对这些化合物进行体外测试；结果以pA2表示。
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