Graziadei G, Pruneri G, Carboni N, Luminari S, Targia M L, Neri A, Colombi M, Buffa R, Baldini L
Department of Hematology, Centro G. Marcora, Italy.
Ann Hematol. 1998 Feb;76(2):81-3. doi: 10.1007/s002770050367.
Mucosa-associated lymphoid tissue (MALT) lymphomas are indolent neoplasms which tend to remain localized for a long time before spreading. We describe here the case of a 36-year-old woman with a low-grade MALT lymphoma involving the lung, stomach, lingual tonsil, and bone marrow at the time of diagnosis. The clonal origin of the pulmonary and bone marrow neoplastic infiltrates was assessed by means of gene rearrangement analysis. All of the involved sites were infiltrated by centrocyte- and monocytoid-like cells expressing the B-cell-associated antigens CD19 and CD20 and showed IgM lambda chain restriction; no CD5, CD10, or CD43 expression was detectable. As the patient had a history of recurrent bronchitis, and computed tomography performed 3 years before the lymphoma diagnosis had already revealed a lesion of the left lung, we conclude that the present case probably represents a pulmonary low-grade MALT lymphoma characterized by an early and unusual involvement of different mucosal sites and bone marrow.
黏膜相关淋巴组织（MALT）淋巴瘤是惰性肿瘤，在扩散之前往往会长期局限于局部。我们在此描述一例36岁女性，诊断时患有低级别MALT淋巴瘤，累及肺、胃、舌扁桃体和骨髓。通过基因重排分析评估肺和骨髓肿瘤浸润的克隆起源。所有受累部位均被表达B细胞相关抗原CD19和CD20的中心细胞样和单核细胞样细胞浸润，并显示IgM λ链限制性；未检测到CD5、CD10或CD43表达。由于该患者有复发性支气管炎病史，且淋巴瘤诊断前3年进行的计算机断层扫描已显示左肺有病变，我们得出结论，本病例可能代表一种肺低级别MALT淋巴瘤，其特征为不同黏膜部位和骨髓早期且不寻常的受累。
