Lesot H, Peterková R, Viriot L, Vonesch J L, Turecková J, Peterka M, Ruch J V
INSERM U424, Institut de Biologie Médicale, Faculté de Médecine, Strasbourg, France.
Eur J Oral Sci. 1998 Jan;106 Suppl 1:64-70. doi: 10.1111/j.1600-0722.1998.tb02155.x.
Computer-aided 3D reconstructions were used to investigate early odontogenesis in the ICR mouse, from the dental lamina to the cap stage. The diastemal region of the maxilla was not an empty zone: five transient epithelial rudiments (D1-D5) were found between ED 12.5-13.5. Two further rudiments (R1 and R2) were observed between D5 and the maxillary first molar primordium, whose bud emerged at ED 13.5. These rudiments might be related to vestiges of ancestral teeth. During this period, only an epithelial lamina was observed in front of the bud-shaped molar epithelium in the cheek region of the mandible. Apoptosis plays an important role in the reduction of antemolar rudiments in the maxilla and in the remodeling of the epithelium anterior to the M1 bud and cap in both jaws: two successive waves of apoptosis were detected in the mandible and in the maxilla. Computer-aided 3D reconstructions clearly demonstrated that morphologically different developmental stages coexist along the anteroposterior axis of M1 in both jaws.
利用计算机辅助三维重建技术研究了ICR小鼠从牙板到帽状期的早期牙发生过程。上颌的牙间隙区域并非空区：在胚胎第12.5 - 13.5天之间发现了五个短暂的上皮原基（D1 - D5）。在D5与上颌第一磨牙原基之间观察到另外两个原基（R1和R2），其牙蕾在胚胎第13.5天出现。这些原基可能与祖先牙齿的遗迹有关。在此期间，在下颌颊部区域的芽状磨牙上皮前方仅观察到一个上皮板。细胞凋亡在上颌前磨牙原基的减少以及上下颌M1牙蕾和帽状期之前上皮的重塑中起重要作用：在下颌和上颌中检测到两波连续的细胞凋亡。计算机辅助三维重建清楚地表明，形态上不同的发育阶段沿上下颌M1的前后轴共存。
