Pilipili C M, Goret-Nicaise M, Dhem A
University of Louvain (UCL), School of Dental Medicine, Brussels, Belgium.
Eur J Oral Sci. 1998 Jan;106 Suppl 1:429-36. doi: 10.1111/j.1600-0722.1998.tb02210.x.
In order to explore the bony changes in the mandibular body during prefunctional intraosseous eruption of premolars, 18 dogs aged from 8 to 16 wk at the beginning of experimental period, were given two intraperitoneal injections of oxytetracycline (50 mg/kg and 35 mg/kg 2 wk later) and 2 wk later a final injection of Alizarin red S (70 mg/kg). Microradiographic and fluorescent light microscopy studies showed that changes of the alveolar bony crypt walls were influenced by the growing dental germs which they surrounded. The cervical volumetric reduction, which indicates the end of crown formation, induced the apposition of lamellar and then woven bone on the adjacent alveolar walls. Furthermore, with occlusal displacement of the dental crown, the space below the tooth was immediately filled with woven bone trabeculae and chondroid tissue. The same phenomenon was observed at the level of the alveolar base, when the speed of tooth eruption was greater than that of root growth. During premolar development, the changes in the dental germ produces accommodating changes in the adjacent alveolar bone walls, and mandibular transversal growth has the same characteristics as that of a growing diaphysis.
为了探究前磨牙在功能性骨内萌出前期下颌体的骨质变化，选取18只实验开始时年龄为8至16周的犬，腹腔注射两次土霉素（50mg/kg，2周后注射35mg/kg），2周后再注射一次茜素红S（70mg/kg）。显微放射摄影和荧光显微镜研究表明，牙槽骨隐窝壁的变化受其周围生长的牙胚影响。牙冠形成结束时出现的颈部体积减小，促使相邻牙槽壁上有板层骨继而有编织骨附着。此外，随着牙冠向咬合面移位，牙齿下方的间隙立即被编织骨小梁和类软骨组织填充。当牙齿萌出速度大于牙根生长速度时，在牙槽基部也观察到同样的现象。在前磨牙发育过程中，牙胚的变化会使相邻牙槽骨壁产生适应性变化，下颌横向生长与骨干生长具有相同的特征。
