Hirschberg R, Ding H
Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
Semin Nephrol. 1998 Mar;18(2):191-207.
During acute renal injury, there are alterations in the expression of several growth factors and their receptors in the kidney. The increased expression of several growth factors and/or their receptors at sites of nephron injury suggests important contributions to repair. Exogenous administration of some growth factors, such as IGF-I, EGF and HGF, accelerates recovery of renal function in experimental acute renal failure (ARF). In ARF growth factors act through several mechanisms, which may include altered cell cycle regulation and mitogenesis, differentiation of recovered cells, regulation of apoptosis, improved renal hemodynamics, and others. There is evidence for interactions of growth factors with other growth factors as well as with other genes resulting in complex orchestration of biologic events contributing to recovery from ARF.
在急性肾损伤期间，肾脏中几种生长因子及其受体的表达会发生改变。肾单位损伤部位几种生长因子和/或其受体表达的增加表明它们对修复有重要作用。外源性给予某些生长因子，如胰岛素样生长因子-I（IGF-I）、表皮生长因子（EGF）和肝细胞生长因子（HGF），可加速实验性急性肾衰竭（ARF）中肾功能的恢复。在急性肾衰竭中，生长因子通过多种机制发挥作用，这些机制可能包括改变细胞周期调控和有丝分裂、恢复细胞的分化、凋亡调控、改善肾血流动力学等。有证据表明生长因子与其他生长因子以及其他基因相互作用，导致参与急性肾衰竭恢复的生物事件的复杂协调。
