渗出性年龄相关性黄斑病变中的全血硒含量
Whole blood selenium in exudative age-related maculopathy.
作者信息
Mayer M J, van Kuijk F J, Ward B, Glucs A
机构信息
Psychology and Psychobiology, SSII, University of California, Santa Cruz 95064, USA.
出版信息
Acta Ophthalmol Scand. 1998 Feb;76(1):62-7. doi: 10.1034/j.1600-0420.1998.760111.x.
PURPOSE
We tested whether exudative ARM was associated with low whole blood levels of selenium (Se).
METHODS
Blood samples, drawn from 10 exudative ARM patients (61.2-76.1 yr) and 9 healthy-eyed (66.9-75.1 yr) subjects, were analyzed by atomic absorption spectroscopy.
RESULTS
Selenium concentration was significantly lower in the ARM group (186.6 microg/l) than in controls (207.0 microg/l). Because many ARM patients took Se supplements, we tested the effect on blood Se of 80 microg per day of sodium selenate. We found no enduring effects of supplementation for healthy-eyed, younger adults.
CONCLUSIONS
Significant group differences in this preliminary study indicate a larger-scale study of blood Se concentration in exudative ARM patients is warranted. If the effect of Se supplementation on the progression of exudative ARM is tested in future trials, it will be important to use organic Se, to identify the components of blood affected, and to observe protocol for at least six months.
目的
我们测试了渗出性年龄相关性黄斑变性（ARM）是否与全血硒（Se）水平低有关。
方法
通过原子吸收光谱法分析从10名渗出性ARM患者（61.2 - 76.1岁）和9名视力正常的受试者（66.9 - 75.1岁）采集的血样。
结果
ARM组的硒浓度（186.6微克/升）显著低于对照组（207.0微克/升）。由于许多ARM患者服用了硒补充剂，我们测试了每天80微克硒酸钠对血硒的影响。我们发现补充剂对视力正常的年轻成年人没有持久影响。
结论
这项初步研究中的显著组间差异表明有必要对渗出性ARM患者的血硒浓度进行更大规模的研究。如果未来试验测试硒补充剂对渗出性ARM进展的影响，使用有机硒、确定受影响的血液成分以及观察至少六个月的方案将很重要。
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