Jenssen D, Renberg L
Chem Biol Interact. 1976 Aug;14(3-4):279-89.
The phenoxyacetic acids 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), extensively used as herbicides, were tested for cytogenetic effects by means of induced micronuclei in erythrocytes of mouse bone marrow. Because of the hig experimental resolution power this is a particularly suitable test system for the detection of weak chromosome breaking activity in mammals. The cytogenetic tests were supplemented with chemical analyses of the concentration the the test substances reaching the target cells...
苯氧乙酸类除草剂2,4-二氯苯氧乙酸（2,4-D）和2,4,5-三氯苯氧乙酸（2,4,5-T）被广泛使用，通过检测小鼠骨髓红细胞中的诱导微核来测试其细胞遗传学效应。由于该实验具有较高的分辨率，这是一种特别适合检测哺乳动物中微弱染色体断裂活性的测试系统。细胞遗传学测试还辅以对到达靶细胞的测试物质浓度的化学分析……
