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V79中国仓鼠细胞中的染色体内端粒重复序列与截短染色体的稳定性

Intrachromosomal telomeric repeats and stabilization of truncated chromosomes in V79 Chinese hamster cells.

作者信息

Simi S, Attolini C, Giulotto E

机构信息

Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy.

出版信息

Mutat Res. 1998 Feb 2;397(2):229-33. doi: 10.1016/s0027-5107(97)00217-0.

Abstract

(TTAGGG)n sequences have been localized on the chromosomes of the Chinese hamster V79 cell line. A correlation between telomeric-like repeats and chromosome breakage has been found. Moreover, the analysis of the truncated chromosomes, typical of this cell line, has suggested that intrachromosomal (TTAGGG)n DNA may be important in the stabilization of the new telomeres.

摘要

(TTAGGG)n序列已定位在中国仓鼠V79细胞系的染色体上。已发现端粒样重复序列与染色体断裂之间存在相关性。此外,对该细胞系典型的截短染色体的分析表明,染色体内的(TTAGGG)n DNA可能在新端粒的稳定中起重要作用。

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