急性心肌梗死治疗及二级预防中辅助治疗的病理生理基础。
Pathophysiologic bases for adjunctive therapies in the treatment and secondary prevention of acute myocardial infarction.
作者信息
Gutstein D E, Fuster V
机构信息
Cardiovascular Institute, Mount Sinai Medical Center, New York, New York 10029-6574, USA.
出版信息
Clin Cardiol. 1998 Mar;21(3):161-8. doi: 10.1002/clc.4960210305.
Abstract
Postmyocardial infarction (MI) survival has been steadily improving. This improvement has been due, in part, to the actions of the adjunctive medical therapies for the treatment of MI. Aspirin, beta blockers, angiotensin-converting enzyme (ACE) inhibitors, and lipid-lowering agents have been shown to improve survival in the treatment and secondary prevention of MI. Nitrates have beneficial effects as well. These medications complement the reperfusion strategies through different mechanisms. Other adjunctive medical therapies, namely magnesium, antiarrhythmic agents, and calcium-channel blockers, have not been shown to improve mortality with routine post-MI use despite their theoretical benefits.
摘要
心肌梗死后的生存率一直在稳步提高。这种提高部分归功于用于治疗心肌梗死的辅助药物治疗措施。阿司匹林、β受体阻滞剂、血管紧张素转换酶（ACE）抑制剂和降脂药物已被证明可改善心肌梗死治疗及二级预防中的生存率。硝酸盐类药物也有有益作用。这些药物通过不同机制补充再灌注策略。其他辅助药物治疗措施，即镁剂、抗心律失常药物和钙通道阻滞剂，尽管有理论上的益处，但在心肌梗死后常规使用时并未显示能降低死亡率。
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