Fernandes M H
Faculdade de Medicina Dentária, Universidade do Porto.
Acta Med Port. 1998 Jan;11(1):41-52.
The bone is continuously in a remodelling process. Bone mass is maintained in a continuous balance between its destruction and formation. Bone remodelling proceeds in a highly regulated cycle in which osteoclasts adhere to bone and subsequently remove it by acidification and proteolytic digestion and the osteoblasts secrete a organic matrix which is calcified into new bone. Bone remodelling is the cellular basis of bone metabolism. Pathological changes in many metabolic bone diseases can be explained by abnormalities at some point of the remodelling cycle. The mechanisms of regulatory bone metabolism involve the availability of a number of minerals and ionic homeostasis, systemic hormones and numerous local factors. In this work the general pattern of bone remodelling and the cellular mechanisms of bone resorption and formation are briefly described. The role of systemic and local factors in the regulation and coupling of these two processes is also reported.
骨骼持续处于重塑过程中。骨量在其破坏与形成之间保持着持续的平衡。骨重塑以高度调控的周期进行，其中破骨细胞附着于骨骼，随后通过酸化和蛋白水解消化将其去除，而成骨细胞分泌有机基质，该基质钙化形成新骨。骨重塑是骨代谢的细胞基础。许多代谢性骨病的病理变化可通过重塑周期某些点的异常来解释。调节骨代谢的机制涉及多种矿物质的可用性和离子稳态、全身激素以及众多局部因素。在这项工作中，简要描述了骨重塑的一般模式以及骨吸收和形成的细胞机制。还报道了全身和局部因素在这两个过程的调节和耦合中的作用。
