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[鼻脑型毛霉菌病的治疗综述]

[Treatment review in rhinocerebral mucormycosis].

作者信息

Pardal Refoyo J L, Chocarro Martínez A, Brezmes Valdivieso M F, Parra Pérez C

机构信息

Hospital Virgen de la Concha, Insalud, Zamora.

出版信息

An Otorrinolaringol Ibero Am. 1998;25(1):45-56.

PMID:9542247
Abstract

The rhinocerebral mucormycosis is the more common form produced by Rhizopus, a genus of fungi. It's a serious infective disease with high mortality, that needs a precocious medical treatment. Amphotericin B is the choice medical treatment, but liposomal amphotericine B in recent years is a better drug, due to minor renal toxicity and greater tisular diffusion. Even can not to treat all affected areas it's necessary an extensive surgical treatment according to individual characteristics and disease evolution. A 56-year-old man with rhinocerebral mucormycosis, caused by Rhizopus, who was treated with liposomal-amphotericin B and extensive rhino-orbital surgery is presented.

摘要

鼻脑型毛霉病是由根霉属真菌引起的较常见类型。它是一种严重的感染性疾病,死亡率高,需要早期治疗。两性霉素B是首选治疗药物,但近年来脂质体两性霉素B是更好的药物,因为其肾毒性较小且组织扩散性更强。即使不能治疗所有受影响区域,也有必要根据个体特征和疾病进展进行广泛的手术治疗。本文介绍了一名56岁因根霉引起鼻脑型毛霉病的男性患者,他接受了脂质体两性霉素B治疗和广泛的鼻眶手术。

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