糖尿病和非糖尿病妊娠的人胎盘葡萄糖转运蛋白（GLUT 1、GLUT 3）信使核糖核酸

Glucose transporters (GLUT 1, GLUT 3) mRNA in human placenta of diabetic and non-diabetic pregnancies.

作者信息

Sciullo E, Cardellini G, Baroni M, Torresi P, Mazziotti F, Pozzilli P, Fallucca F

机构信息

Cattedra di Diabetologia, Università degli Studi La Sapienza, Rome, Italy.

出版信息

Ann Ist Super Sanita. 1997;33(3):361-5.

PMID:9542263

Abstract

Glucose transporters (GLUT) catalyse the transport of glucose in many human tissues, including the placenta. On the other hand glucose concentrations can affect both glucose transport activity and level of GLUT mRNA and protein. Up to now very few studies, concerning GLUT in the placenta appeared and studies in vivo in human diabetic pregnancy are lacking. Therefore we investigated placental GLUT 1 and GLUT 3 mRNA in 10 diabetic (5 IDDM, 2 NIDDM, 3 GDM) and 9 non-diabetic women. GLUT 1 mRNA was found significantly correlated with maternal age (> 30 vs < 30 years: p < 0.025), with placental weight (> 575 vs < 575 g: p < 0.05), while GLUT 3 mRNA decreased significantly in late gestation of diabetic women (38-40 vs < 38 weeks: p < 0.025). In addition GLUT 3 was significantly lower in the diabetic than in non-diabetic women in late gestation. These preliminary results deserve to better elucidate feto-maternal carbohydrate metabolism at the placental level in normal as well as diabetic pregnancy.

摘要

葡萄糖转运蛋白（GLUT）催化葡萄糖在包括胎盘在内的许多人体组织中的转运。另一方面，葡萄糖浓度可影响葡萄糖转运活性以及GLUT mRNA和蛋白质水平。到目前为止，关于胎盘中GLUT的研究很少，且缺乏对人类糖尿病妊娠的体内研究。因此，我们调查了10名糖尿病患者（5名胰岛素依赖型糖尿病、2名非胰岛素依赖型糖尿病、3名妊娠期糖尿病）和9名非糖尿病女性胎盘的GLUT 1和GLUT 3 mRNA。发现GLUT 1 mRNA与产妇年龄（>30岁与<30岁：p<0.025）、胎盘重量（>575 g与<575 g：p<0.05）显著相关，而糖尿病女性妊娠晚期GLUT 3 mRNA显著下降（38 - 40周与<38周：p<0.025）。此外，妊娠晚期糖尿病女性的GLUT 3明显低于非糖尿病女性。这些初步结果值得进一步阐明正常及糖尿病妊娠胎盘水平的母婴碳水化合物代谢情况。