Gold C H, Buchanan N, Tringham V, Viljoen M, Strickwold B, Moodley G P
Clin Nephrol. 1976 Aug;6(2):365-9.
INH pharmcokinetics was studied in 2 groups of patients in chronic renal failure. In the group on conservative treatment, INH half life was prolonged, but was not related to the degree on renal impairement. In the hemodialysis group 73% of the INH given was removed by dialysis within 5 hours. If INH is to be used in the presence of renal failure, individual half life estimations should be performed in order to determine dosage frequency. In patients on hemodialysis, therapy should be given post dialysis. Alternatively, drugs not dependent on renal failure, e.g. rifampicin, may be preferable.
在两组慢性肾衰竭患者中研究了异烟肼的药代动力学。在保守治疗组中，异烟肼半衰期延长，但与肾功能损害程度无关。在血液透析组中，给予的异烟肼有73%在5小时内被透析清除。如果在肾衰竭患者中使用异烟肼，应进行个体半衰期估计以确定给药频率。对于接受血液透析的患者，应在透析后给药。或者，使用不依赖肾衰竭的药物，如利福平，可能更可取。
