Ferrante M E, Quatela M M, Corbo G M, Pistelli R, Fuso L, Valente S
Military Hospital Rome.
Mil Med. 1998 Mar;163(3):180-3.
In this paper, we present data on the prevalence of sinusitis and its relationship to bronchial asthma in 120 young male asthmatics evaluated without exacerbations of their disease. All patients reported respiratory symptoms during the preceding year, and in the most of them (74%), the severity of asthma was mild. Sinusitis was observed in 52 patients (43.3%), and the maxillary sinus was involved in 36 asthmatics. Sixteen of 52 patients with sinusitis had never had nasal symptoms of rhinitis. In all patients, physical examination of the lung was negative for wheezing. All patients had FEV1 (forced expiratory volume/forced vital capacity x 100 in 1 second of expiration) values in the normal range, and bronchial hyperresponsiveness was detected in 101 asthmatics (84.2%). One hundred sixteen patients (96.6%) were found to be skin reactors. We did not find statistical differences between asthmatics with or without sinusitis with regard to severity of asthma, basal lung function, and bronchial hyperresponsiveness. We suggest that antibiotic therapy for sinusitis should be given only to asthmatics with worsening respiratory symptoms and obvious signs of chronic sinusitis.
在本文中，我们呈现了120例无疾病加重期的年轻男性哮喘患者鼻窦炎患病率及其与支气管哮喘关系的数据。所有患者均报告在前一年有呼吸道症状，其中大多数（74%）哮喘病情为轻度。52例患者（43.3%）存在鼻窦炎，36例哮喘患者上颌窦受累。52例鼻窦炎患者中有16例从未有过鼻炎的鼻部症状。所有患者肺部体格检查未闻及哮鸣音。所有患者第一秒用力呼气容积（FEV1，用力呼气量/用力肺活量×100）值均在正常范围内，101例哮喘患者（84.2%）检测到支气管高反应性。116例患者（96.6%）为皮肤反应者。在哮喘病情严重程度、基础肺功能和支气管高反应性方面，我们未发现有或无鼻窦炎的哮喘患者之间存在统计学差异。我们建议，仅应对呼吸道症状加重且有慢性鼻窦炎明显体征的哮喘患者给予鼻窦炎抗生素治疗。
