Grigg A, Chapman R, Szer J
Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Victoria, Australia.
Bone Marrow Transplant. 1998 Mar;21(6):619-21. doi: 10.1038/sj.bmt.1701126.
Fludarabine has been associated with an increased risk of opportunistic infections, possibly related to the induction of profound CD4+ lymphopenia. We observed two cases of cytomegalovirus pneumonia (CMV-IP) in a total of nine patients over a 5-year period who had previously received fludarabine and who proceeded to autografting. Both patients also received steroids post-transplant. CMV-IP was observed in one of 104 other autograft recipients over this time who had not received prior fludarabine. This observation suggests that the combination of fludarabine pre-transplant and steroids post-transplant may increase the risk of invasive CMV disease in autograft recipients.
氟达拉滨与机会性感染风险增加有关，这可能与诱导严重的CD4+淋巴细胞减少有关。在5年期间，我们在总共9例先前接受过氟达拉滨并进行自体移植的患者中观察到2例巨细胞病毒肺炎（CMV-IP）。两名患者移植后也接受了类固醇治疗。在此期间，在其他104例未接受过氟达拉滨的自体移植受者中，有1例观察到CMV-IP。这一观察结果表明，移植前使用氟达拉滨和移植后使用类固醇可能会增加自体移植受者发生侵袭性CMV疾病的风险。
