Takahashi T, Kanda Y, Mori M, Saito T, Chiba S, Mitani K, Hirai H, Yazaki Y
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Bone Marrow Transplant. 1998 Mar;21(6):623-5. doi: 10.1038/sj.bmt.1701143.
Hemophagocytic syndrome (HPS) associated with T cell lymphoma is well known, but an association with B cell lymphoma is rare. We report a patient who developed subcutaneous non-Hodgkin's lymphoma (NHL) of B cell origin. Autologous peripheral blood stem cell transplantation (PBSCT) was undertaken in her second complete remission (CR), but HPS appeared 5 months after transplantation. The patient deteriorated rapidly and died of metabolic acidosis. Necropsy revealed that she had relapsed B cell NHL involving liver, spleen and bone marrow. B cell NHL after PBSCT, associated with HPS as an initial sign, is rare. We report this case and review the literature.
噬血细胞综合征（HPS）与T细胞淋巴瘤相关已广为人知，但与B细胞淋巴瘤相关则较为罕见。我们报告了一名发生B细胞起源的皮下非霍奇金淋巴瘤（NHL）的患者。在她第二次完全缓解（CR）时进行了自体外周血干细胞移植（PBSCT），但移植后5个月出现了HPS。患者病情迅速恶化，死于代谢性酸中毒。尸检显示她的B细胞NHL复发，累及肝脏、脾脏和骨髓。PBSCT后出现的B细胞NHL，以HPS作为初始表现，十分罕见。我们报告此病例并复习相关文献。
