Reale M, Frydas S, Barbacane R C, Placido F C, Cataldo I, Vacalis D, Trakatellis A, Anogianakis G, Felaco M, Di Gioacchino M, Conti P
Immunology Division, University of Chieti School of Medicine, Italy.
Mol Cell Biochem. 1998 Feb;179(1-2):1-5. doi: 10.1023/a:1006875429323.
MCP-1 is a small (8-10 KDa) protein and a prototype member of the CC chemokine beta subfamily, which plays a critical role in acute and chronic inflammation. Recent evidence suggests an important role for MCP- 1, MCP-2 and MCP-3 in a number of pathological states, including delayed type hypersensitivity conditions, parasitic infections and rheumatoid arthritis. Forty BALB-c mice were treated with the parasite Trichinella spiralis. After the infection the animals were sacrificed at different periods from the initial infection and MCP-1 and TNFalpha were quantified in the mouse serum. The level of MCP-1 in the serum of mice infected with 100 larvae increases from 27.5+/-7.0 pg/ml at day 23, to a maximum level of 31.5+/-5.0 pg/ml at day 33, then decreased to 14.6+/-2.0 pg/ml at day 47. When the mice were infected with 200 larvae of T. spiralis the maximum increase was 34.4+/-2.5 pg/ml found on day 23. From day 33 to day 47 MCP-1 levels were decreased. In addition, in infected mice levels of TNFalpha were detectable in the serum as early as day 1. The level of TNFalpha was maximum at day 35 (3812+/-224 pg/ml). Serum from non-infected mice contained no detectable levels of either MCP-1 or TNFalpha. However, even if MCP-1 seems to be implicated in Trichinellosis, its exact role and function in inflammatory parasitic diseases remains to be determined.
单核细胞趋化蛋白-1（MCP-1）是一种小分子（8-10千道尔顿）蛋白质，是CC趋化因子β亚家族的原型成员，在急性和慢性炎症中起关键作用。最近的证据表明，MCP-1、MCP-2和MCP-3在许多病理状态中发挥重要作用，包括迟发型超敏反应、寄生虫感染和类风湿性关节炎。40只BALB-c小鼠感染旋毛虫。感染后，在感染初期后的不同时间段处死动物，并对小鼠血清中的MCP-1和肿瘤坏死因子α（TNFα）进行定量。感染100条幼虫的小鼠血清中MCP-1水平从第23天的27.5±7.0皮克/毫升增加到第33天的最高水平31.5±5.0皮克/毫升，然后在第47天降至14.6±2.0皮克/毫升。当小鼠感染200条旋毛虫幼虫时，第23天发现的最大增幅为34.4±2.5皮克/毫升。从第33天到第47天，MCP-1水平下降。此外，在感染小鼠中，血清中早在第1天就可检测到TNFα水平。TNFα水平在第35天最高（3812±224皮克/毫升）。未感染小鼠的血清中未检测到MCP-1或TNFα水平。然而，即使MCP-1似乎与旋毛虫病有关，但其在炎症性寄生虫病中的确切作用和功能仍有待确定。
