Osorio A, Ruiz E, Ortega E
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Spain.
Mol Cell Biochem. 1998 Feb;179(1-2):7-11. doi: 10.1023/a:1006867109759.
We have monitored estrous cycle and measured serum estradiol, GH, IGF-1, T4 and T3 levels in adult hypothyroid female rats which were divided into four groups: H group, hypothyroid rats without treatment; H-T4 group, hypothyroid rats injected daily with T4; HT4-PTU group, hypothyroid rats injected daily with T4 plus PTU (propylthiouracil), and H-T4-IOP group, hypothyroid rats injected daily with T4 plus IOP (iopanoic acid); Euthyroid rats (E group) were used as control. Our results indicate that the lack of sexual cycle in H animals was associated with lower values of estradiol, GH and IGF-1 in comparison to E group; the restoration of sexual cycle in H-T4 group was associated with values of estradiol, GH and IGF-1 higher than those of H group, whereas in H-T4-PTU and H-T-IOP groups the restoration was associated with higher values of GH and IGF-1 and values of estradiol similar to those of H group. These data could suggest a potential role of GH/IGF-1 axis, at least in part, in the lack of sexual cycle in H group and in the ovulation induction in H-T4, H-T4-PTU and H-T4-IOP groups.
我们监测了成年甲状腺功能减退雌性大鼠的发情周期，并测量了血清雌二醇、生长激素（GH）、胰岛素样生长因子-1（IGF-1）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平。这些大鼠被分为四组：H组，未治疗的甲状腺功能减退大鼠；H-T4组，每天注射T4的甲状腺功能减退大鼠；HT4-PTU组，每天注射T4加丙硫氧嘧啶（PTU）的甲状腺功能减退大鼠，以及H-T4-IOP组，每天注射T4加碘番酸（IOP）的甲状腺功能减退大鼠；正常甲状腺大鼠（E组）作为对照。我们的结果表明，与E组相比，H组动物缺乏性周期与雌二醇、GH和IGF-1值较低有关；H-T4组性周期的恢复与雌二醇、GH和IGF-1值高于H组有关，而在H-T4-PTU组和H-T-IOP组中，恢复与GH和IGF-1值较高以及与H组相似的雌二醇值有关。这些数据可能表明，GH/IGF-1轴至少在一定程度上在H组性周期缺乏以及H-T4、H-T4-PTU和H-T4-IOP组排卵诱导中发挥潜在作用。
