Eggert P, Müller D, Schröter T
Universitäts-Kinderklinik, Kiel, Germany.
Pediatr Nephrol. 1998 Feb;12(2):144-6. doi: 10.1007/s004670050425.
Idiopathic hypercalciuria (IH) associated with nephrocalcinosis was found in three of six siblings. After the three affected children were maintained on a low-calcium diet, they demonstrated increasing hypercalciuria, parathyroid hormone, and vitamin D3 levels. An oral calcium loading test was not necessary to diagnose renal IH. During treatment with hydrochlorothiazide, the calcium excretion was normalized. These patients are remarkable because nephrocalcinosis is generally regarded as a rare complication of renal IH. Moreover, the fact that three of six siblings are affected raises the question of whether the renal form of IH is genetically distinct from other forms of IH.
在六个兄弟姐妹中，有三人被发现患有与肾钙质沉着症相关的特发性高钙尿症（IH）。在三名患病儿童维持低钙饮食后，他们的高钙尿症、甲状旁腺激素和维生素D3水平却不断升高。诊断肾性IH无需进行口服钙负荷试验。在使用氢氯噻嗪治疗期间，钙排泄恢复正常。这些患者很值得关注，因为肾钙质沉着症通常被认为是肾性IH的一种罕见并发症。此外，六个兄弟姐妹中有三人患病，这就引发了一个问题，即肾性IH在基因上是否与其他形式的IH不同。
