Gorelick D A, Montoya I D, Johnson E O
Division of Intramural Research, National Institute of Drug Abuse, National Institute of Health, Baltimore, MD 21224, USA.
Drug Alcohol Depend. 1998 Jan 1;49(2):89-93. doi: 10.1016/s0376-8716(97)00143-9.
This study evaluated: (1) the reporting of sociodemographic characteristics of research subjects in published outpatient studies of cocaine abuse pharmacotherapy; (2) the association of study characteristics with such reporting and with the distribution of characteristics; and (3) the comparison of sociodemographic characteristics in the research subjects with those of a community-based sample of cocaine abusers who had sought treatment. Medline search identified 68 articles on cocaine abuse outpatient pharmacotherapy published from 1983 to 1993 in an English language, peer-reviewed journal. Sociodemographic characteristics of research subjects (n = 1802) were compared with those of respondents (weighted n = 135) to the National Comorbidity Survey (1990-1992), who reported at least one cocaine-related problem and had sought substance abuse treatment. Only three (4.4%) articles reported all six of the following sociodemographic characteristics of their subjects: 82.4%, reported mean age; 58.8%, race/ethnicity; 85.3%, sex; 22.1%, employment status; 13.2%, educational status; and 5.9%, socioeconomic status/income. Compared to survey respondents, research subjects were significantly more likely to be African-American and live in the Northeast region of the US and marginally more likely to be male and currently unemployed. These findings indicate that many published articles do not follow currently recommended guidelines for describing sociodemographic characteristics of research subjects and that, aside from race/ethnicity and geographic location, research subjects are fairly comparable in basic sociodemographic characteristics to the larger population of treatment-seeking individuals with cocaine-related problems.
（1）已发表的可卡因滥用药物治疗门诊研究中研究对象的社会人口学特征报告情况；（2）研究特征与此类报告以及特征分布之间的关联；（3）研究对象的社会人口学特征与寻求治疗的社区可卡因滥用样本的社会人口学特征的比较。通过对医学期刊数据库（Medline）的检索，确定了1983年至1993年期间在英文同行评审期刊上发表的68篇关于可卡因滥用门诊药物治疗的文章。将研究对象（n = 1802）的社会人口学特征与全国共病调查（1990 - 1992年）的受访者（加权n = 135）进行比较，这些受访者报告了至少一个与可卡因相关的问题并寻求过药物滥用治疗。只有三篇（4.4%）文章报告了其研究对象的以下所有六项社会人口学特征：82.4%报告了平均年龄；58.8%报告了种族/民族；85.3%报告了性别；22.1%报告了就业状况；13.2%报告了教育状况；5.9%报告了社会经济地位/收入。与调查受访者相比，研究对象更有可能是非裔美国人且居住在美国东北部地区，并且略更有可能是男性且目前失业。这些发现表明，许多已发表的文章未遵循目前推荐的描述研究对象社会人口学特征的指南，并且除了种族/民族和地理位置外，研究对象在基本社会人口学特征方面与寻求治疗的可卡因相关问题的更大人群相当。
