Point D, Coudert P, Leal F, Rubat C, Sautou-Miranda V, Chopineau J, Couquelet J
Laboratoire de Pharmacie Clinique et Biotechnique, Faculté de Pharmacie, Clermont-Ferrand, France.
Farmaco. 1998 Jan;53(1):85-8. doi: 10.1016/s0014-827x(97)00012-8.
Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 x 10(-4) M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.
已经合成了一些4-苯甲酰基-3-羟基呋喃-2（5H）酮（3a-d）和2-氨基-3-羟甲基-4-芳基-4-氧代-2-丁烯酸（4a-h）。呋喃环5位带有异丁基取代基的化合物3c在清除超氧阴离子方面最有效（IC50 = 8.69×10⁻⁴ M）。在体内，3c对再灌注损伤也有保护作用。
