Eriksson K, Erilä T, Kivimäki T, Koivikko M
Medical School, University of Tampere, Finland.
Am J Ment Retard. 1998 Mar;102(5):464-72. doi: 10.1352/0895-8017(1998)102<0464:eoeicw>2.0.co;2.
Various aspects of epilepsy, including its evolution, were studied in 78 children with mental retardation in a prospective 5-year (1989-1994) follow-up study. Level of mental retardation was moderate or even more severe (IQ < 50) in 83% of children, and 56% suffered from significant cerebral palsy. Epilepsy remained uncontrolled in 28% of cases, 2-year remission was achieved by 26%, and mortality was 12% during the study period. Associated cerebral palsy was the most important single risk factor for severe epilepsy, and several handicaps seemed to have a strong multiplicative effect. Complexity of epilepsy in children with mental retardation was reflected by the evolutionary features described.
在一项为期5年（1989 - 1994年）的前瞻性随访研究中，对78名智力发育迟缓儿童的癫痫各个方面，包括其演变情况进行了研究。83%的儿童智力发育迟缓程度为中度甚至更严重（智商<50），56%患有严重脑瘫。在研究期间，28%的病例癫痫仍未得到控制，26%实现了2年缓解，死亡率为12%。合并脑瘫是严重癫痫最重要的单一危险因素，多种残疾似乎具有很强的相乘效应。所描述的演变特征反映了智力发育迟缓儿童癫痫的复杂性。
