Holtom P D, Warren C A, Greene N W, Bravos P D, Ressler R L, Shepherd L, McPherson E J, Patzakis M J
Department of Clinical Medicine and Orthopaedics, University of Southern California, Los Angeles, USA.
Am J Orthop (Belle Mead NJ). 1998 Mar;27(3):207-10.
To study the relationship between surface area and antibiotic elution from antibiotic-impregnated polymethylmethacrylate (PMMA) spacers, a standard block spacer made of vancomycin (4 g) and 40 g of PMMA was compared with two unique spacer designs, the "donut" and "fenestrated." The spacers were incubated in phosphate-buffered saline, which was changed daily, and a microbiologic assay was used to measure the antibiotic activity of the eluates. The donut and fenestrated spacers had 12% and 40% more surface area than the standard spacer, respectively. There was no significant difference, however, in daily elution levels of antibiotic between the donut spacer and the standard spacer. The fenestrated spacer displayed significantly better elution than either the standard or donut spacers, with an average of 20% more antibiotic eluted on any given day.
为研究抗生素负载聚甲基丙烯酸甲酯（PMMA）间隔物的表面积与抗生素洗脱之间的关系，将由万古霉素（4克）和40克PMMA制成的标准块状间隔物与两种独特的间隔物设计“甜甜圈”型和“带孔”型进行比较。将间隔物置于每日更换的磷酸盐缓冲盐水中孵育，并用微生物测定法测量洗脱液的抗生素活性。“甜甜圈”型和“带孔”型间隔物的表面积分别比标准间隔物大12%和40%。然而，“甜甜圈”型间隔物与标准间隔物之间的每日抗生素洗脱水平没有显著差异。“带孔”型间隔物的洗脱效果明显优于标准间隔物和“甜甜圈”型间隔物，在任何给定日期平均多洗脱20%的抗生素。
