Greene N, Holtom P D, Warren C A, Ressler R L, Shepherd L, McPherson E J, Patzakis M J
Department of Orthopaedic Surgery, University of Southern California School of Medicine, Los Angeles, USA.
Am J Orthop (Belle Mead NJ). 1998 Mar;27(3):201-5.
In vitro studies of antibiotic elution from polymethylmethacrylate cement comparing Simplex (Howmedica, Rutherford, NJ) with Palacos brands (Richards, Memphis, TN) have shown variable results. This study compares the elution of tobramycin and vancomycin from Simplex and Palacos beads and spacers. Six-millimeter beads and spacers were incubated in phosphate-buffered saline, and the solution was sampled and changed daily until the concentration of antibiotic fell below the minimum inhibitory concentration (MIC) for Staphylococcus aureus. In all groups, the Palacos PMMA beads and spacers showed elution at higher levels and remained above the MIC longer than did the Simplex PMMA beads. Tobramycin had superior elution to vancomycin in all groups. This in vitro study shows that Palacos PMMA has superior elution properties to Simplex PMMA in tobramycin and vancomycin beads and spacers.
比较Simplex（豪美迪卡公司，新泽西州卢瑟福）和Palacos品牌（理查兹公司，田纳西州孟菲斯）的聚甲基丙烯酸甲酯骨水泥抗生素洗脱的体外研究显示结果各异。本研究比较了妥布霉素和万古霉素从Simplex和Palacos珠子及间隔物中的洗脱情况。将6毫米的珠子和间隔物置于磷酸盐缓冲盐水中孵育，每天对溶液进行采样并更换，直至抗生素浓度降至金黄色葡萄球菌的最低抑菌浓度（MIC）以下。在所有组中，Palacos聚甲基丙烯酸甲酯珠子和间隔物的洗脱水平更高，且在MIC以上保持的时间比Simplex聚甲基丙烯酸甲酯珠子更长。在所有组中，妥布霉素的洗脱效果优于万古霉素。这项体外研究表明，在妥布霉素和万古霉素珠子及间隔物方面，Palacos聚甲基丙烯酸甲酯比Simplex聚甲基丙烯酸甲酯具有更好的洗脱性能。
