Roach P J, Cooper R A, Arthur C K, Ravich R B
Department of Nuclear Medicine, Royal North Shore Hospital, St Leonards, NSW.
Aust N Z J Med. 1998 Feb;28(1):33-8. doi: 10.1111/j.1445-5994.1998.tb04456.x.
Gallium-67 (Ga-67) is widely used in the assessment of patients with lymphoma. Although highly sensitive in Hodgkin's disease and high grade non-Hodgkin's lymphoma (NHL), its sensitivity is reported to be reduced in lower grades of NHL. Several series have suggested that thallium-201 (Tl-201) may be more useful than Ga-67 in the evaluation of low and possibly intermediate grade NHL.
To compare the sensitivity and relative avidities (uptakes) of Tl-201 and Ga-67 in patients with NHL.
A total of 36 pairs of studies were performed in 33 patients (14 male: 19 female; age range 16-84 years, mean 55 years). All had whole body Ga-67 (400 MBq) and Tl-201 (100-200 MBq) studies (interval 0-three days) which were read by two experienced nuclear medicine physicians blinded to clinical history and results of other investigations.
Tl-201 had a higher sensitivity and avidity than Ga-67 in patients with low grade NHL. In contrast, Ga-67 was slightly more sensitive and had a higher avidity in patients with both intermediate and high grade NHL.
We conclude that Tl-201 is more sensitive and avid for low grade NHL than Ga-67 and that consideration should be given to its use in this condition in conjunction with Ga-67 as it may provide complementary information. Routine use in intermediate grade NHL is less convincing as Ga-67 was superior in most cases. Ga-67 is more sensitive than Tl-201 in assessment of high grade NHL.
镓-67（Ga-67）广泛应用于淋巴瘤患者的评估。尽管它在霍奇金病和高级别非霍奇金淋巴瘤（NHL）中具有高度敏感性，但据报道在低级别NHL中其敏感性会降低。一些系列研究表明，铊-201（Tl-201）在评估低级别及可能的中级别NHL时可能比Ga-67更有用。
比较Tl-201和Ga-67在NHL患者中的敏感性和相对摄取率（摄取情况）。
对33例患者（14例男性，19例女性；年龄范围16 - 84岁，平均55岁）进行了总共36对研究。所有患者均进行了全身Ga-67（400 MBq）和Tl-201（100 - 200 MBq）检查（间隔0 - 3天），由两名对临床病史和其他检查结果不知情的经验丰富的核医学医师进行解读。
在低级别NHL患者中，Tl-201比Ga-67具有更高的敏感性和摄取率。相比之下，在中级别和高级别NHL患者中，Ga-67的敏感性略高且摄取率更高。
我们得出结论，对于低级别NHL，Tl-201比Ga-67更敏感且摄取率更高，在这种情况下应考虑将其与Ga-67联合使用，因为它可能提供补充信息。在中级别NHL中常规使用的说服力较小，因为在大多数情况下Ga-67更具优势。在评估高级别NHL时，Ga-67比Tl-201更敏感。
