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[伯尔尼州的麻疹疫情]

[Measles outbreaks in the Bern canton].

作者信息

Maurer A M, Mühlemann K

机构信息

Institut für Medizinische Mikrobiologie, Universität Bern.

出版信息

Schweiz Med Wochenschr. 1998 Feb 28;128(9):317-22.

PMID:9544458
Abstract

Currently, overall vaccination coverage against measles among infants ranges between 77% and 89% in Switzerland. Experience in other countries has shown that this level of vaccination is not sufficient to prevent measles outbreaks, especially among schoolchildren. During 1992 surveillance for measles outbreaks in closed populations was conducted in the Canton of Berne. Outbreaks were investigated for vaccine efficacy. Two measles outbreaks in schoolchildren were observed during the study period. In 2 Bernese suburban schools 6 measles cases in children (median age 12.5 years) occurred over a period of 37 days. One of the cases had been vaccinated. Vaccination rate in the healthy control children was 89.7%. Estimated vaccine efficacy was 97.7% (95% confidence interval [CI]: 68%, 99%). The second outbreak occurred in a rural region and comprised 21 measles cases (median age 7.5 years) within 43 days. 10 (47.6%) of the cases attended the same school. None of the cases had been vaccinated. Of the healthy control children 82.6% had received measles vaccine. Estimated vaccine efficacy was 100% (CI: 87%, 100%). These two measles outbreaks were due to failure to vaccinate rather than low vaccine efficacy. Surveillance for measles cases is currently not sufficient for the detection of measles outbreaks in our population. Laboratory confirmation of measles, especially in vaccinated persons, has become more important in a time of relatively low measles incidence.

摘要

目前,瑞士婴儿的麻疹总体疫苗接种率在77%至89%之间。其他国家的经验表明,这种疫苗接种水平不足以预防麻疹疫情,尤其是在学龄儿童中。1992年期间,伯尔尼州对封闭人群中的麻疹疫情进行了监测。对疫情进行了疫苗效力调查。在研究期间观察到两起学龄儿童麻疹疫情。在伯尔尼的两所郊区学校,37天内有6名儿童(中位年龄12.5岁)出现麻疹病例。其中1例曾接种过疫苗。健康对照儿童的疫苗接种率为89.7%。估计疫苗效力为97.7%(95%置信区间[CI]:68%,99%)。第二起疫情发生在农村地区,43天内有21例麻疹病例(中位年龄7.5岁)。其中10例(47.6%)就读于同一所学校。所有病例均未接种过疫苗。健康对照儿童中82.6%接种过麻疹疫苗。估计疫苗效力为100%(CI:87%,100%)。这两起麻疹疫情是由于未接种疫苗而非疫苗效力低所致。目前,对麻疹病例的监测不足以发现我国人群中的麻疹疫情。在麻疹发病率相对较低的时期,麻疹的实验室确诊,尤其是对已接种疫苗者的确诊,变得更加重要。

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