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毛发分析显示多药滥用的证据:一例涉及海洛因、可卡因、大麻、氯仿、硫喷妥钠和氯胺酮的致命案例。

Evidence of polydrug use using hair analysis: a fatal case involving heroin, cocaine, cannabis, chloroform, thiopental and ketamine.

作者信息

Gaillard Y, Pépin G

机构信息

Laboratoired' Expertises TOXLAB, Paris, France.

出版信息

J Forensic Sci. 1998 Mar;43(2):435-8.

PMID:9544560
Abstract

A case is presented involving a young woman on several illicit drugs (heroin, cocaine and cannabis) as well as two medications and a solvent used for their anesthetic and narcotic properties: thiopental, ketamine and chloroform. This complex drug use was supported by hair analysis over a 10.5 cm segment of the hair taken at autopsy. The average measured concentrations in hair were: thiopental = 5.3 ng/mg, pentobarbital = 10.0 ng/mg, ketamine = 11.3 ng/mg norketamine = 1.0 ng/mg, diazepam = 1.2 ng/mg, nordiazepam = 0.1 ng/mg, 6-acetylmorphine = 4.4 ng/mg, morphine = 3.4 ng/mg, codeine = 1.2 ng/mg, cocaine = 5.5 ng/mg, benzoylecgonine = 1.5 ng/mg and methylecgonine ester = 1.0 ng/mg. While the ketamine/norketamine ratio is consistent with that already reported on drug detection in hair, the thiopental/pentobarbital ratio seems to be inverted.

摘要

本文介绍了一个案例,涉及一名年轻女性,她使用了多种非法药物(海洛因、可卡因和大麻)以及两种具有麻醉和致幻特性的药物和一种溶剂:硫喷妥钠、氯胺酮和氯仿。尸检时采集的10.5厘米长的头发样本分析证实了这种复杂的药物使用情况。头发中测得的平均浓度为:硫喷妥钠=5.3纳克/毫克,戊巴比妥=10.0纳克/毫克,氯胺酮=11.3纳克/毫克,去甲氯胺酮=1.0纳克/毫克,地西泮=1.2纳克/毫克,去甲地西泮=0.1纳克/毫克,6-单乙酰吗啡=4.4纳克/毫克,吗啡=3.4纳克/毫克,可待因=1.2纳克/毫克,可卡因=5.5纳克/毫克,苯甲酰爱康宁=1.5纳克/毫克,甲基爱康宁酯=1.0纳克/毫克。虽然氯胺酮/去甲氯胺酮的比例与已报道的头发药物检测结果一致,但硫喷妥钠/戊巴比妥的比例似乎颠倒了。

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