Browning D J, Antoszyk A N
Charlotte Eye, Ear, Nose, and Throat Associates, North Carolina 28204, USA.
Ophthalmology. 1998 Apr;105(4):670-7; discussion 677-9. doi: 10.1016/S0161-6420(98)94022-2.
This study aimed to test the efficacy and safety of laser chorioretinal anastomosis for central retinal vein occlusion (CRVO).
The study design was a consecutive case series.
Eight eyes of eight patients were treated.
The argon laser was used in the method of McAllister and Constable to attempt to form an anastomosis. The patients were observed for 1 to 19 months (median, 11 months).
Visual acuity, anastomosis success, and complications were measured.
Twenty attempts to create anastomoses were made with 2 successful anastomoses but not of a therapeutic type. Three patients developed rubeosis, retinal neovascularization at the laser site, and vitreous hemorrhage. Traction retinal detachment occurred twice and neovascular glaucoma occurred once. Secondary panretinal photocoagulation, pars plana vitrectomy, and glaucoma seton were required in three patients, one patient, and one patient, respectively. Visual acuity improved in two patients independent of failed attempts at anastomosis creation and did not improve or worsened in six patients, including the two patients with the successfully created anastomoses.
Laser chorioretinal anastomosis for nonischemic CRVO has greater risks and less success than the initial report suggested. Further refinement of the technique is needed before it is adopted extensively. Even when successful, macular pigment epithelial scarring can limit vision, implying a relatively short time window for its effective application in the face of severe macular edema. Successful laser chorioretinal anastomosis does not preclude development of anterior segment neovascularization.
本研究旨在测试激光脉络膜视网膜吻合术治疗视网膜中央静脉阻塞(CRVO)的疗效和安全性。
本研究设计为连续病例系列。
8例患者的8只眼接受了治疗。
采用麦卡利斯特和康斯特布尔的方法使用氩激光试图形成吻合。对患者进行了1至19个月(中位数为11个月)的观察。
测量视力、吻合成功情况及并发症。
进行了20次吻合尝试,但仅有2次成功吻合,不过并非治疗性吻合。3例患者出现虹膜新生血管、激光部位视网膜新生血管及玻璃体积血。发生牵拉性视网膜脱离2次,新生血管性青光眼1次。分别有3例、1例和1例患者需要进行二期全视网膜光凝、玻璃体切割术及青光眼引流装置植入术。2例患者视力改善,与吻合尝试失败无关;6例患者视力未改善或恶化,包括2例成功形成吻合的患者。
对于非缺血性CRVO,激光脉络膜视网膜吻合术的风险比最初报告显示的更大,成功率更低。在广泛应用之前,需要进一步完善该技术。即使成功,黄斑色素上皮瘢痕形成也可能限制视力,这意味着在面对严重黄斑水肿时其有效应用的时间窗口相对较短。成功的激光脉络膜视网膜吻合术并不能预防眼前段新生血管形成。