Pugliese A
G Batteriol Virol Immunol. 1979 Jan-Jun;72(1-6):78-114.
In this review some interesting aspects of interferon and its present perspectives for a practical utilization in human viral infections and in oncological therapy are described. After an evaluation of general characteristics of IF, some particular problems are considered about this system as that of IF and poly I:C interaction with cellular membranes, genetic control of IF system, IF and its inducers influence on immune reactivity and human tumours cells IF inducing ability and sensitivity. Finally are described some data obtained in various Institutes with IF on human virosis and those obtained on human and animal oncology with IF and interferon inducers.
本综述描述了干扰素的一些有趣方面及其在人类病毒感染和肿瘤治疗中的实际应用前景。在评估了干扰素的一般特性后，考虑了关于该系统的一些特殊问题，如干扰素和聚肌胞苷酸与细胞膜的相互作用、干扰素系统的基因控制、干扰素及其诱导剂对免疫反应性的影响以及人类肿瘤细胞的干扰素诱导能力和敏感性。最后，描述了各机构在人类病毒感染方面使用干扰素获得的数据，以及在人类和动物肿瘤学方面使用干扰素和干扰素诱导剂获得的数据。
