Voris J C, Shaurette G N, Sebastian P S, Will-Wallace L A
Department of Clinical Pharmacy, College of Pharmacy, University of South Carolina, Dorn Veterans Hospital, Columbia 29209-1639, USA.
Pharmacotherapy. 1998 Mar-Apr;18(2):379-80.
This pilot study involved six men with major depression treated with nefazodone dosed either twice/day or once/day at bedtime. Depression was rated before nefazodone therapy and at 4 weeks by the self-report version of the Hamilton Depression Rating Scale. A simple 10-cm visual analog side effect scale for daytime drowsiness was completed at the latter time. Dosages of nefazodone were at least 400 mg/day. The results suggest that nefazodone given once/day at bedtime may be as effective as the currently accepted twice/day regimen, with less daytime drowsiness.
这项试点研究涉及6名重度抑郁症男性患者，他们接受了奈法唑酮治疗，给药方式为每日两次或每日一次（睡前服用）。在接受奈法唑酮治疗前以及治疗4周时，采用汉密尔顿抑郁量表的自评版本对抑郁程度进行评分。在治疗4周时，还完成了一个简单的10厘米视觉模拟副作用量表，用于评估日间嗜睡情况。奈法唑酮的剂量至少为400毫克/天。结果表明，睡前每日一次服用奈法唑酮可能与目前公认的每日两次给药方案效果相同，但日间嗜睡情况较少。
