Tsuji Y, Fukuda M, Tomimasu K, Yoshinaga M, Takayanagi T, Nakashita S, Kusumoto T, Tanaka H, Hayashi K
Department of Pediatrics, School of Medicine, Nagasaki University.
Jpn J Antibiot. 1997 Dec;50(12):967-74.
Pharmacokinetic and clinical evaluation of an injectable cephem antibiotics, cefozopran (SCE-2787, CZOP), was conducted in newborn patients and the following results were obtained: 1. Clinical results The clinical efficacy of CZOP was evaluated in one each patient with intrauterine infection and suspected septicemia. The efficacy was "excellent" in both patients. No clinically serious adverse drug reactions of signs and symptoms and abnormal alterations of the laboratory test values were recognized. 2. Pharmacokinetics CZOP was intravenously given to newborn patients at doses of 25.0, 20.0, and 18.75 mg/kg. The blood CZOP concentrations were 44.7 +/- 7.0 micrograms/ml (n = 3), 48.3 micrograms/ml and 48.2 micrograms/ml at one hour after administration, respectively. The elimination half life (T 1/2) was 4.22 +/- 1.17 hours (n = 3) in the patients given 25.0 mg/kg and 2.74 hours in the patient given 20.0 mg/kg. The urinary drug excretion rate was 44.5 +/- 8.7% and 31.3 +/- 9.7% of dose within 8 hours after administration of 25.0 mg/kg and 20.0 mg/kg, respectively.
对一种注射用头孢菌素类抗生素头孢唑兰（SCE - 2787，CZOP）在新生儿患者中进行了药代动力学和临床评估，获得以下结果：1. 临床结果 在1例宫内感染患者和1例疑似败血症患者中评估了CZOP的临床疗效。两名患者的疗效均为“优秀”。未发现有临床严重的药物不良反应体征和症状以及实验室检查值的异常改变。2. 药代动力学 以25.0、20.0和18.75mg/kg的剂量给新生儿患者静脉注射CZOP。给药后1小时血中CZOP浓度分别为44.7±7.0μg/ml（n = 3）、48.3μg/ml和48.2μg/ml。给予25.0mg/kg的患者消除半衰期（T1/2）为4.22±1.17小时（n = 3），给予20.0mg/kg的患者为2.74小时。给予25.0mg/kg和20.0mg/kg后8小时内尿药排泄率分别为剂量的44.5±8.7%和31.3±9.7%。
