Chevrel J P, Damsin J P, Lebhar E
Nouv Presse Med. 1979 Jan 6;8(1):27-30.
A so-called "phase II" clinical trial was carried out in 89 patients with digestive carcinomas who were treated either by chemotherapy alone or by a combination of surgery and chemotherapy. Thirty-five patients with inoperable tumours received chemotherapy alone without any noticeable improvement. Thirty-two patients had tumours which were operable but with inoperable extension. Palliative chemotherapy, given after surgery to reduce the size of the tumour, resulted in a prolongation of survival. Twenty-two patients with operable tumours without inoperable extension benefited from routine adjuvant chemotherapy.
一项所谓的“II期”临床试验在89例消化道癌患者中进行，这些患者要么仅接受化疗，要么接受手术与化疗相结合的治疗。35例无法手术的肿瘤患者仅接受化疗，未出现任何明显改善。32例患者的肿瘤可以手术，但有无法手术切除的扩散。术后给予姑息性化疗以缩小肿瘤大小，从而延长了生存期。22例可手术且无无法手术切除扩散的肿瘤患者受益于常规辅助化疗。
