Alon E, Jaquenod M, Pasch T
Institut für Anästhesiologie, Universitätsspital Zürich.
Praxis (Bern 1994). 1998 Feb 25;87(9):300-4.
Opioids have been accepted as appropriate analgesic treatment for pain associated with cancer. However, controversy exists about their use for chronic noncancer pain. Reasons for reluctance are concerned about efficacy and potential adverse effects such as respiratory depression, addiction, physical dependence or intolerance. Many physicians worry about liability and legal restrictions. Nevertheless, pain management of chronic severe pain with opioids can be the only help when alternative methods are too risky of fail to be effective. This article briefly reviews the published literature on this topic and discusses some practical guidelines for the use of opioids in the treatment of non-cancer pain.
阿片类药物已被公认为是治疗癌症相关疼痛的合适镇痛药。然而，对于它们用于慢性非癌性疼痛存在争议。不愿使用的原因涉及疗效以及诸如呼吸抑制、成瘾、身体依赖或不耐受等潜在不良反应。许多医生担心责任问题和法律限制。尽管如此，当替代方法风险太大或无效时，用阿片类药物治疗慢性重度疼痛可能是唯一的办法。本文简要回顾了关于该主题的已发表文献，并讨论了在治疗非癌性疼痛中使用阿片类药物的一些实用指南。
