Yu J, Shen Y, Tong S, Kao F T
Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206, USA.
Somat Cell Mol Genet. 1997 Sep;23(5):367-70. doi: 10.1007/BF02674283.
Three unique sequence microclones from human chromosome region 21q11 were assigned to mouse chromosome 16 using a mouse/Chinese hamster cell hybrid 96Az2 containing a single mouse chromosome 16. This comparative mapping provides further homology between human chromosome 21 and mouse chromosome 16 to include the very proximal portion of the long arm of human chromosome 21. Since this part of human chromosome 21 is associated with mental retardation in Down syndrome individuals, its homologous mouse region should also be included in the construction of mouse models for studying Down syndrome phenotypes including mental retardation.
利用含有单一小鼠16号染色体的小鼠/中国仓鼠细胞杂种96Az2，将来自人类21号染色体区域21q11的三个独特序列微克隆定位到小鼠16号染色体上。这种比较图谱绘制进一步揭示了人类21号染色体与小鼠16号染色体之间的同源性，包括人类21号染色体长臂的最近端部分。由于人类21号染色体的这一部分与唐氏综合征患者的智力发育迟缓有关，在构建用于研究包括智力发育迟缓在内的唐氏综合征表型的小鼠模型时，也应纳入其同源的小鼠区域。
