Stamler J S, Hausladen A
Nat Struct Biol. 1998 Apr;5(4):247-9. doi: 10.1038/nsb0498-247.
The molecular basis of redox sensitivity in proteins is not well understood. Here we consider a continuum of NO- and O2-related modifications of cysteine residues that constitute biological signaling events on the one hand and hallmarks of nitrosative and oxidative stresses on the other.
蛋白质中氧化还原敏感性的分子基础尚未得到充分理解。在此,我们考虑了半胱氨酸残基与一氧化氮(NO)和氧气(O₂)相关的一系列修饰,这些修饰一方面构成了生物信号事件,另一方面则是亚硝化和氧化应激的标志。